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. 2018 Sep 24;62(10):e01252-18. doi: 10.1128/AAC.01252-18

FIG 1.

FIG 1

Phase I and II metabolism of lumefantrine shows the conversion of lumefantrine to desbutyl-lumefantrine by CYP3A4, a cytochrome P450, and the subsequent conversion of desbutyl-lumefantrine to a more polar metabolite by a uridine-glucuronosyltransferase (UGT) isoform.