TABLE 3.
Bactericidal activity of LYS228 against 271 Enterobacteriaceae isolates
| Test agent | No. (%) of isolates with MBC/MIC ratioa of: |
||||
|---|---|---|---|---|---|
| 1 | 2 | 4 | 8 | >8 | |
| LYS228 | 196 (72.3) | 52 (19.2) | 16 (5.9) | 7 (2.6) | |
| Aztreonam | 216 (79.7) | 37 (13.7) | 10 (3.7) | 8 (3.0) | |
| Ceftazidime | 223 (82.3) | 29 (10.7) | 12 (4.4) | 7 (2.6) | |
| Ceftazidime-avibactamb | 196 (72.3) | 51 (18.8) | 16 (5.9) | 8 (3.0) | |
| Cefepime | 194 (71.6) | 45 (16.6) | 16 (5.9) | 16 (5.9) | |
| Meropenem | 197 (72.7) | 40 (14.7) | 21 (7.7) | 13 (4.8) | |
| Tigecycline | 46 (17.0) | 20 (7.4) | 12 (4.4) | 14 (5.2) | 179 (66.1) |
a
For MBC/MIC ratio calculations, MIC and MBC values of ≤0.06 μg/ml were set to 0.06 μg/ml and MIC and MBC values of >64 μg/ml were set to 128 μg/ml.
b
Avibactam was tested at a fixed concentration of 4 μg/ml.