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Kinetic and equilibrium binding constants for compounds binding to E. coli PBP3 determined by stopped-flow fluorimetrya
| Compound | k2 (s−1) | 95% CI (s−1) | Kd (μM) | 95% CI (μM) | k2/Kd (s−1 M−1) |
|---|---|---|---|---|---|
| LYS228 | 162.4 ± 26.4 | 78.4 to 246.4 | 441.9 ± 90 | 153.6 to 730.3 | 367,504.0 |
| ATM | 147.2 ± 5.9 | 128.4 to 166.1 | 359.7 ± 20 | 298.9 to 420.5 | 409,229.9 |
| CFS | <10 | NA | ≫1,000 | NA | NA |
CI, confidence interval. NA, not applicable due to insufficient binding.
