FIG 2.

Activity of the sPBTZ derivative 11626091 (50 mg/kg) compared to in vivo activity of INH (10 mg/kg) or MCZ (25 mg/kg) in the mouse model of chronic TB. Black columns correspond to the bacterial burden in lungs, and red columns correspond to the bacterial burden in the spleens at day zero (Day 0) when treatment was initiated, or day 28 (NT) when treatment ended. Bars represent the means ± the standard deviations of CFU from five mice per group. NT, untreated control. Limit of detection, 20 CFU/organ. The significance of difference was calculated using a Student t test (*, P < 0.05; **, P < 0.005; ***, P < 0.0001 [compared to NT]).