FIG 1.
Benznidazole treatment in both the acute and chronic stage cures C3H/HeN mice infected with T. cruzi JR strain. (A) Outline of infection and treatment schedule. Mice were treated with 100 mg/kg benznidazole once daily by the oral route for 20 days (Materials and Methods). (B) Representative ventral in vivo images of treated (starting day 14 or 73) and nontreated mice at sequential time points postinfection. All images use the same log10-scale heat-map with minimum and maximum radiance values as indicated. (C) Ex vivo bioluminescence images of organs and tissues taken at 152 days postinfection (dpi). Organs arranged as shown (upper image).