TABLE 2.
Single amino acid substitutions found in AmpC proteins from 46 clinical isolates of B. multivoransa
| Strain(s) | Amino acid substitution(s), insertion(s), or deletion(s) | No. of differences | Refseq protein accession no. | AmpC designation |
|---|---|---|---|---|
| ATCC 17616, AU21747, AU17545, AU19729, AU10398, AU19518, AU14371, AU28069, AU25543, AU30760, AU20929 | 0 | WP_012218336.1 | AmpC1 | |
| AU19564 | L104P | 1 | WP_105845787.1 | AmpC2 |
| AU13919, AU14328 | T229V, G241A, R309P | 3 | WP_105776316.1 | AmpC3 |
| AU10897 | G98A, T229V, K290T, A363E | 4 | WP_105758864.1 | AmpC4 |
| AU17534 | D76A, T229A, G241A, K290T | 4 | WP_105783420.1 | AmpC5 |
| AU23995 | A129V, R139H, T229A, I244T, A363E | 5 | WP_105810139.1 | AmpC6 |
| AU4507 | A74V, R176Q, T229A, G241A, A363E | 5 | WP_006416937.1 | AmpC7 |
| AU24277 | P18S, T205A, T229A, I244T, A363E | 5 | WP_105835089.1 | AmpC8 |
| AU12481 | A137T, T205A, T229A, I244T, R261Q | 5 | WP_105789398.1 | AmpC9 |
| AU29198 | TL11 M, T229A, D230E, K290T, P304S | 5 | WP_105844745.1 | AmpC10 |
| AU23668 | L104V, A124E, V143 M, T229A, G362D, A363E | 6 | WP_105813500.1 | AmpC11 |
| AU14364 | TL16S, T4A, T229A, G241A, G362D, A363E | 6 | WP_105765510.1 | AmpC12 |
| AU11233 | TL11S, I11F, I33V, E79Q, M184L, T229A, I244T | 7 | WP_105770301.1 | AmpC13 |
| AU26250, AU15954, AU22892 | TL11 M, V89I, R196S, T229V, I244T, K290T, A363E | 7 | WP_105780250.1 | AmpC14 |
| AU15814 | TL16S, T4A, T111A, T229A, G241A, G362D, A363E | 7 | WP_105764661.1 | AmpC15 |
| AU30441 | H7R, I8V, S47A, A141V, T229A, G241A, Q249R, A363D | 8 | WP_105811053.1 | AmpC16 |
| AU30050 | S47A, A141V, D193A, T205A, T229A, G241A, Q249R, A363D | 8 | WP_105793891.1 | AmpC17 |
| AU21015 | I8V, P18S, A165S, D190N, T205A, T229V, I245T, R309P | 8 | WP_107998461.1 | AmpC18 |
| AU14786, AU11772, AU23919 | A17V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, A363D | 9 | WP_105767194.1 | AmpC19 |
| AU11358 | TL22S, H7R, I8V, S47A, A141V, T205A, T229A, G241A, Q249R, A363D | 10 | WP_105775307.1 | AmpC20 |
| AU22436 | H7R, I8V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, A363D | 10 | WP_006405341.1 | AmpC21 |
| AU17135, AU10047, AU28442 | H7R, I8V, S47A, A141V, D193A, T229A, G241A, Q249R, P281S, I352 M, A363E | 11 | WP_105752596.1 | AmpC22 |
| AU16734 | H7R, I8V, S47A, A141V, D193A, T229A, G241A, Q249R, P281S, L305R, A363E | 11 | WP_105792096.1 | AmpC23 |
| AU23690, AU11204 | TL22S, H7R, I8V, S47A, A141V, D193A, T229A, G241A, Q249R, P281S, A363E | 11 | WP_105761708.1 | AmpC24 |
| AU19659 | H7R, I8V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, P281S, L305R, A363E | 12 | WP_105807900.1 | AmpC25 |
| AU30438 | TL22S, H7R, I8V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, V278I, A363E | 12 | WP_105847138.1 | AmpC26 |
| AU25057 | TL22S, H7R, I8V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, P281S, A363E | 12 | WP_105838144.1 | AmpC27 |
| AU27706, AU23365 | TL22S, H7R, I8V, I11V, S47A, A141V, D193A, T205A, T229A, G241A, Q249R, A279E, A363E | 13 | WP_069221591.1 | AmpC28 |
| AU18096, AU21596, AU10086 | No class C β-lactamase found |
a
The AmpC sequences were compared to that of AmpC1 from B. multivorans ATCC 17616.