TABLE 3.
Pharmacokinetic parameter estimates for the final population modela
| Parameter | Final model |
Bootstrap (n = 1,000) |
||
|---|---|---|---|---|
| Estimate | % RSE | Median | 95% PI | |
| CL (liters h−1) | 3.06 | 18.3 | 3.02 | 2.2–4.2 |
| ∼CLCR | 1.55 | 33.9 | 1.58 | 0.5–2.4 |
| V1 (liters) | 14.4 | 2.9 | 14.5 | 13.7–15.4 |
| ∼WT | 0.918 | 15.5 | 0.919 | 0.6–1.3 |
| V2 (liters) | 17.1 | 23.3 | 17.5 | 10.4–28 |
| Q (liter h−1) | 0.925 | 14.9 | 0.913 | 0.6–1.2 |
| % CV for IIV for CL | 20 | 37.8 | 19.5 | 12.7–27.1 |
| Proportional residual variability (%) | 16.61 | 12.3 | 16.2 | 14.1–18.2 |
a
CL, clearance; CLCR, creatinine clearance; CV, coefficient of variation; IIV, interindividual variability; PI, prediction interval; Q, intercompartmental clearance; RSE, relative standard error; V1, central compartment volume; V2, peripheral compartment volume; WT, weight; ~, covariate associated to the PK parameter.