TABLE 2.

Values of free antibiotic concentrations and changes of α- and β-diversity indices between D₀ and D₃ according to vital status at D₁₆ in antibiotic-treated groups for each study and their respective areas under the ROC curves for predicting occurrence of death by D₁₆

Antibiotic and parameter	Median (minimum, maximum) value for mice that:		P valuec	AUROC (95% CI)
	Dieda	Survivedb
Moxifloxacin
Concn	110.0 (70.5, 172.7)	52.9 (0.0, 162.1)	0.00025	0.87 (0.76, 0.95)
α diversity
Change of Shannon index	−1.7 (−3.0, −1.0)	−1.0 (−1.9, 0.1)	<10−4	0.91 (0.80, 0.98)
Change of no. of OTUs	−135.9 (−207.3, −52.2)	−72.9 (−201.0, 74.5)	0.001	0.83 (0.67, 0.95)
Change of Chao1 index	−137.9 (−213.4, −46.2)	−75.5 (−229.3, 83.5)	0.002	0.81 (0.64, 0.93)
β diversity
UniFrac distance
Unweighted	0.61 (0.56, 0.76)	0.51 (0.37, 0.65)	<10−5	0.95 (0.90, 0.99)
Weighted	0.33 (0.24, 0.48)	0.26 (0.13, 0.57)	0.02	0.73 (0.58, 0.87)
Bray-Curtis dissimilarity	0.78 (0.63, 0.86)	0.60 (0.31, 0.87)	<10−4	0.91 (0.81, 0.99)
Clindamycin
Concn	5.0 (0.0, 37.8)	0.0 (0.0, 4.4)	<10−6	0.81 (0.72, 0.91)
α diversity
Change of Shannon index	−2.2 (−4.3, −0.4)	−1.1 (−2.6, 0.0)	<10−6	0.88 (0.78, 0.96)
Change of no. of OTUs	−223.9 (−344.6, −75.8)	−106.8 (−202.2, −22.0)	<10−5	0.86 (0.75, 0.95)
Change of Chao1 index	−227.7 (−358.2, −73.8)	−110.0 (−209.0, −22.7)	<10−6	0.86 (0.76, 0.95)
β diversity
UniFrac distance
Unweighted	0.71 (0.59, 0.84)	0.60 (0.49, 0.68)	<10−10	0.94 (0.88, 0.99)
Weighted	0.42 (0.24, 0.62)	0.30 (0.24, 0.59)	<10−6	0.87 (0.76, 0.96)
Bray-Curtis dissimilarity	0.86 (0.71, 0.98)	0.70 (0.61, 0.87)	<10−9	0.92 (0.84, 0.97)

^an = 10 for the moxifloxacin study and 28 for the clindamycin study.

^bn = 60 for the moxifloxacin study and 32 for the clindamycin study.

^cBy the nonparametric Wilcoxon test.