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In vivo MK-8591 plasma concentration-versus-time profiles in male Wistar Han rats from a series of bioerodible, PLA (a) and PCL (b), and nonerodible EVA (c) implants. Data represent mean ± standard deviation (SD) of n = 4 subjects for all studies. Blue circles, 40 wt% MK-8591 plus 60 wt% polymer; red squares, 50 wt% MK-8591 plus 50 wt% polymer; green triangles, 60 wt% MK-8591 plus 40 wt% polymer; purple inverted triangles, 80 wt% MK-8591 plus 20 wt% polymer.
