TABLE 1.

Final population pharmacokinetic estimates and bootstrap results for ceftriaxone plasma concentrations and dried blood spot-derived plasma concentration for 10 pediatric patients

Parameterb	Plasma parameter		Relative difference in DBS parameter		P valuea
	Estimate	95% CIc	Estimate	95% CI
Objective function value	−143.299	−260.652 to −77.903
Structural model parameters
CL (liters/h/70 kg)	1.05	0.54 to 1.67	1.01	0.9 to 1.17	0.856
VC (liters/70 kg)	5.89	4.29 to 16.82	1.01	0.69 to 1.25	0.706
Q (liters/h/70 kg)	7.38	1.07 to 9.29	0.829	0.63 to 3.49	0.726
VP (liters/70 kg)	10.4	5.21 to 16.2	1.02	0.83 to 1.48	0.542
Variable model parameters [shrinkage %]
IIV in CL	68	17 to 102	1.06	0.8 to 1.2	0.618
IIV in VC	80	5 to 124	0.964	0.67 to 1.3	0.514
RV	25	12 to 34	1.12	0.96 to 1.19	0.23

^aP value obtained from likelihood ratio testing.

^bCL (clearance), V_C (central volume of distribution), Q (intercompartmental clearance), V_P (peripheral volume of distribution), IIV (interindividual variability), and RV (residual variability). IIV presented as $100\%\times \sqrt{\text{variance estimate}}$.

^cCI, confidence interval.