TABLE 1.
Potential repositionable hit compounds identified during the primary screen of the Prestwick library and their corresponding IC50s against C. auris strain 0390 planktonic growth calculated from dose-dependent confirmatory experiments
| Drug Name | Drug type | % inhibition (from primary screen) | IC50 (μM) |
|---|---|---|---|
| R(-)-Apomorphine hydrochloride hemihydrate | Emetic | >90 | 6.928 |
| Suloctidil | Vasodilator | >90 | Not confirmed |
| Ebselen | Anti-inflammatory | >90 | 1.413 |
| Nisoldipine | Antihypertensive | 79 | 29.42 |
| Argatroban | Anticoagulant | >90 (on single plate) | Not confirmed |
| Dimethisoquin hydrochloride | Local anesthetic | 70 | 28.61 |
| Pentetic acid | Chelating agent/radioactive decontaminant | >90 | 11.15 |
| Pentamidine isethionate | Antiparasitic | 87 | 72.94 |
| Pyrvinium pamoate | Antiparasitic | 75 | 7.192 |