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. 2018 May 17;41(9):885–897. doi: 10.1007/s12272-018-1037-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — The timeline for the first applications of engineered nuclease technologies in laboratory animals. The time points when studies that describe the first applications of zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and clustered regularly interspaced short palindromic repeat (CRISPR) system including CRISPR-associated enzyme 9 (Cas9) and CRISPR from Prevotella and Francisella 1 (Cpf1) for genome editing in various laboratory animals were published are marked with colored circles (ZFN, yellow; TALEN, green; Cas9, blue; Cpf1, red)