Safety evidence of IVB and IVR derived from randomized controlled trials and studies in other settings might not be generalizable to the Thai population in routine clinical practice.

This is the first large prospective observational study examining the safety of IVB compared with IVR in Thailand and low- and middle-income countries (LMICs) where there is a lack of appropriate infrastructure for repackaging the pre-filled bevacizumab syringes compared to high-income countries.

This study found low rates of pre-specified serious systemic adverse events and endophthalmitis, which are consistent with the studies conducted in developed countries in terms of the short-term safety profiles of IVB and IVR