Table 3.
Biological activity/physicochemical properties values of selected antipsychotic drugs
| Compound | −ΔH [kcal/mol] | log 1/D | log (1/ED50 × 10−3) | log ATPase activity |
|---|---|---|---|---|
| Aceperon | 0.37 | −1.623 | — | — |
| Acetophenazine | — | — | 2.12 | — |
| Amitriptiline | — | — | 1.85 | — |
| Benperidol | 1.82 | 1.523 | — | — |
| Chlorpromazine | 5.12 | −0.301 | 2.52 | −0.21 |
| Chlorprothixene | 0.19 | 0.022 | 2.57 | — |
| Clomipramine | — | — | 2.22 | — |
| Desipramine | — | — | 1.58 | — |
| Dixyrazine | 4.78 | −0.398 | — | — |
| Droperidol | 0.96 | 1.284 | — | — |
| Fluphenazine | 0.00 | 1.097 | — | — |
| Haloperidol | 5.16 | 1.284 | — | — |
| Imipramine | — | — | 1.79 | −0.99 |
| Levomepromazine | 3.42 | −0.330 | — | — |
| Nortriptiline | — | — | 1.76 | — |
| Perphenazine | — | — | 2.63 | 0.09 |
| Prochlorperazine | 0.00 | 0.137 | 2.75 | 0.87 |
| Promazine | — | — | 2.05 | −1.17 |
| Promethazine | — | — | 1.82 | −0.37 |
| Spiroperidol | 0.69 | 2.000 | — | — |
| Thioproperazine | 0.00 | 0.602 | — | — |
| Thioridazine | — | — | 2.72 | 0.79 |
| Trifluoperazine | — | — | 2.92 | 1.69 |
| Trifluopromazine | — | — | — | 0.27 |
| Triperidol | 5.78 | 1.456 | — | — |