Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 26;75(20):3683–3692. doi: 10.1007/s00018-018-2881-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 3 — a The role of Wnt5a-Ror2 signaling in osteoclast differentiation. Wnt5a-Ror2 signaling increases the expression of RANK in osteoclast precursor cells through the activation of JNK, thereby promoting osteoclast differentiation. b Role of Wnt5a-Ror2 signaling in osteoclast function. Wnt5a-Ror2 signaling activates Rho and then promotes the activity of c-Src in a Pkn3-dependent manner. This signaling pathway enhances the bone-resorbing activity of osteoclasts