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. 2018 Oct;24(10):1825–1834. doi: 10.3201/eid2410.180652

Table. Proportion of circulating influenza viruses with HA amino acid sequences closely matched with vaccine strains, Hong Kong, China, 1996–2012*.

Year, season Influenza A(H3N2) vaccine strains, %†
Influenza B vaccine strains, %†
Northern Hemisphere Southern Hemisphere Northern Hemisphere Southern Hemisphere
1996
Winter None‡ None‡ All§ All§
Summer
None‡
None‡

77.8
77.8
1997
Winter All§ None‡ 14.7 None‡
Summer
94.4
94.4

None‡
None‡
1998
Winter None‡ None‡ None‡ None‡
Summer
None‡
None‡

None‡
None‡
1999
Winter 18.8 None‡ 6.3 6.3
Summer
None‡
None‡

None‡
None‡
2000
Winter None‡ None‡ None‡ None‡
Summer
None‡
None‡

None‡
None‡
2001
Winter All§¶ None‡ None‡ None‡
Summer
84.6¶
84.6¶

None‡
25.0
2002
Winter 41.2¶ 41.2¶ None‡ None‡
Summer
6.7
6.7

12.5
12.5
2003
Winter None‡ None‡ 73.3 6.7
Summer
None‡
None‡

None‡
None‡
2004
Winter None‡ None‡ None‡ None‡
Summer
None‡
None‡

None‡
None‡
2005
Winter 31.3# None‡ 29.4 None‡
Summer
None‡
None‡

12.5
12.5
2006
Winter None‡ None‡ None‡ None‡
Summer
None‡
None‡

None‡
90.0
2007
Winter 52.4 None‡ 9.1 9.1
Summer
6.7
6.7

None‡
None‡
2008
Winter None‡ None‡ 22.2 22.2
Summer
None‡
All§

None‡
None‡
2009
Winter 52.2 52.2 None‡ None‡
Summer**
22.2
22.2

None‡
None‡
2010
Winter None‡ None‡ 66.7 None‡
Summer
None‡
92.9

26.7
26.7
2011
Winter 87.5 87.5 64.3 64.3
Summer
None‡
None‡

37.5
37.5
2012
Winter None‡ None‡ 31.0 31.0
Summer None‡ None‡ None‡ None‡

*Calendar months belonging to winter or summer influenza seasons were based on the average number of cases admitted per month during the study period (Figure 1). Winter seasons were November of previous year through April of current year; influenza usually peaks in February and March. Summer seasons were May–October; influenza usually peaks in July and August. HA, hemagglutinin.
†Co-circulation of multiple strains with a certain percentage closely matched the contemporary vaccine strain based on HA amino acid sequence comparison.
‡None of the circulating viruses examined were closely matched with the contemporary vaccine strain based on HA amino acid sequence comparison.
§All circulating viruses examined were closely matched with the contemporary vaccine strain based on HA amino acid sequence comparison.
¶A/Panama/1999, an alternate to A/Moscow/99, closely matched the circulating strains of 2001 winter and summer seasons and 2002 winter season.
#The World Health Organization recommended 2 A(H3N2) vaccine strains for the Northern Hemisphere in 2005, one of which, A/Wyoming/2003, closely matched a portion of the viruses circulating during the 2005 winter season.
**Dominated by influenza A(H1N1)pdm09.