Table. Serotypes of non–EV-A71 and non–CV-A16 enteroviruses among HFMD cases, by clinical severity, 2013 and 2015, China*.
| Test result |
2013, no. (%) |
|
2015, no. (%) | ||
|---|---|---|---|---|---|
| Mild, n = 87,226 |
Severe, n = 3,837 |
Mild, n = 99,461 |
Severe, n = 4,712 |
||
| EV negative | 32,801 (37.60) | 1,100 (28.67) | 35,167 (35.36) | 1,273 (27.02) | |
| EV-A71 | 15,503 (17.77) | 1,557 (40.58) | 11,800 (11.86) | 1,352 (28.69) | |
| CV-A16 | 10,811 (12.39) | 197 (5.13) | 13,959 (14.03) | 265 (5.62) | |
| Other enteroviruses | 28,111 (32.23) | 983 (25.62) | 38,535 (38.74) | 1,822 (38.67) | |
| Further serotyping of other enteroviruses | |||||
| Total | Mild, n = 3,260† | Severe, n = 42‡ | Mild, n = 2,474§ | Severe, n = 71¶ | |
| CV-A6 | 2,620 (80.37) | 28 (66.67) | 1,471 (59.46) | 31 (43.70) | |
| CV-A10 | 176 (5.40) | 4 (9.52) | 104 (4.20) | # | |
| CV-A2 | 22 (0.67) | 1 (2.38) | 5 (0.20) | # | |
| CV-A5 | 9 (0.28) | 1 (2.38) | 2 (0.08) | # | |
| CV-A4 | 2 (0.06) | # | 9 (0.36) | # | |
| ECV-6 | 9 (0.28) | # | # | # | |
| CV-B4 | 13 (0.4) | # | # | # | |
| ECV-25 | 8 (0.25) | # | # | # | |
| CV-A12 | 5 (0.15) | # | # | # | |
| CV-B5 | 5 (0.15) | # | # | # | |
| CV-B2 | 4 (0.12) | # | 1 (0.04) | # | |
| ECV-7 | 4 (0.12) | # | # | # | |
| ECV-9 | 3 (0.09) | # | # | # | |
| CV-A8 | 1 (0.03) | # | 3 (0.12) | # | |
| CV-A14 | 2 (0.06) | # | # | # | |
| CV-A21 | 2 (0.06) | # | # | # | |
| ECV-12 | 2 (0.06) | # | # | # | |
| CV-B1 | 2 (0.06) | # | # | # | |
| ECV-30 | 1 (0.03) | # | 1 (0.04) | # | |
| Other | 6 (0.18)** | # | # | # | |
| Untyped | 364 (11.37) | 8 (19.05) | 878 (35.49) | 40 (56.34) | |
*CV, coxsackievirus; ECV, echovirus; EV, enterovirus. †Results are based on data from Beijing, Fujian, Guangdong, Guangxi, Heilongjiang, Henan, Hubei, Jiangsu, Jilin, Shanxi, Sichuan, Shandong, Tianjin, Xinjiang, and Yunnan provinces. ‡Results are based on data from Fujian, Guangdong, Guangxi, Henan, and Shanxi provinces. §Results are based on data from Beijing, Fujian, Guangxi, Heilongjiang, Jiangsu, Sichuan, Tianjin, and Zhejiang provinces. ¶Results are based on data from Guangdong and Jiangsu provinces. #The serotypes were not detected, but might be included in the untyped specimens because of laboratory capacity restrictions. **Other serotypes include CV-A20, CV-A24, ECV-1, ECV-96, Polio1, and Polio2, with 1 of each serotype detected.