Figure 5.

Reconstruction of amino acid changes along trunk of lineage C phylogenies of influenza A(H7N9) viruses, China. Maximum clade credibility tree of hemagglutinin gene sequences from lineage C is shown. Branches are colored according to geographic locations, as in Figure 3. Thicker lines indicate the trunk lineage leading up to the current fifth influenza epidemic wave. Amino acid changes along the trunk are indicated. Red branches indicate sites undergoing parallel amino acid changes across multiple lineages. Mutations correspond to H3 numbering scheme. *Mutation sites not present are numbered according to H7 numbering.