Fig. 4.

The effect of acute or chronic administration of 1MeTIQ on lactacystin-induced changes in the 3-MT concentration in the rat striatum. Sham-operated rats received a single injection of saline (control). Lactacystin was infused unilaterally into the right substantia nigra (5 μg) 7 days before the microdialysis study. In the mixed group, 1MeTIQ (50 mg/kg i.p.) was administered acutely (on the day of the experiment) or chronically for seven consecutive days. The dialysate was collected every 20 min. The concentration of 3-MT was measured. The data are expressed as the means ± SEM (n = 6). Statistical significance: *p < 0.05, **p < 0.01 from the basal value (Duncan’s test)