Fig. 5.

The effect of acute or chronic administration of 1MeTIQ on lactacystin-induced changes in the HVA concentration in the rat striatum. Sham-operated rats received a single injection of saline (control). Lactacystin was infused unilaterally into the right substantia nigra (5 μg) 7 days before the microdialysis study. In the mixed group, 1MeTIQ (50 mg/kg i.p.) was administered acutely (on the day of the experiment) or chronically for seven consecutive days. The dialysate was collected every 20 min. The concentration of HVA was measured. The data are expressed as the means ± SEM (n = 6). Statistical significance: *p < 0.05, **p < 0.01 from the basal value (Duncan’s test)