Table 2. Performance metrics (mean ± standard deviation, median) of DOCTAD on 134 6-month volumes before and after fine-tuning both on the initial training set and the subject’s baseline volume using 6-fold cross validation. Statistically significant differences (p-value < 0.05) are shown in bold.

Volumes	Performance metric	Method
		Gold standard (Manual)	Before fine-tuning	After fine-tuning
				On initial training set	On baseline volume
All	EZ defect areas (mm2)	0.71 ± 0.71, 0.54	0.74 ± 0.70, 0.56	0.76 ± 0.72, 0.60	0.78 ± 0.74, 0.61
	DSC	-	0.82 ± 0.16, 0.88	0.82 ± 0.17, 0.88	0.83 ± 0.17, 0.89
	Et (mm2)	-	0.18 ± 0.20, 0.12	0.18 ± 0.20, 0.12	0.17 ± 0.21, 0.11
	En (mm2)	-	0.11 ± 0.17, 0.06	0.12 ± 0.17, 0.06	0.11 ± 0.20, 0.06
CS	EZ defect areas (mm2)	0.87 ± 0.71, 0.70	0.89 ± 0.69, 0.73	0.92 ± 0.71, 0.76	0.93 ± 0.73, 0.76
	DSC	-	0.85 ± 0.12, 0.89	0.85 ± 0.12, 0.89	0.87 ± 0.10, 0.90
	Et (mm2)	-	0.21 ± 0.21, 0.14	0.21 ± 0.21, 0.14	0.20 ± 0.22, 0.13
	En (mm2)	-	0.13 ± 0.18, 0.07	0.13 ± 0.18, 0.08	0.12 ± 0.21, 0.07