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Serum and brain concentrations of tadalafil in mice. Data are presented as the mean ± SEM. Tadalafil (20 mg/kg) was injected i.p. 30, 60, 90, 120, and 240 min before mice decapitation. Experimental groups consisted of 6–10 animals. Serum and brain concentrations of tadalafil are expressed in ng/ml and ng/g, respectively
