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. 2018 Sep 12;9:1936. doi: 10.3389/fimmu.2018.01936

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Copyright © 2018 Frasca, Palazzo, Chimenti, Alivernini, Tolusso, Bui, Botti, Giunta, Bianchi, Petricca, Auteri, Spadaro, Fonti, Falchi, Evangelista, Marinari, Pietraforte, Spinelli, Colasanti, Alessandri, Conti, Gremese, Costanzo, Valesini, Perricone and Lande.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-LL37 antibodies are present in synovial fluids of PsA. Synovial fluids of PsA and OA (N = 11) patients were analyzed by ELISA for the presence of anti-LL37 (PsA, N = 19), anti-LL37cit (PsA, N = 21) and anti-LL37carb (PsA, N = 17). Antibody levels are shown as median with Interquartile Range (IQR). P-value is calculated by two-tailed Mann-Whitney U test, ***p < 0.0001. The mean+2 SD (standard deviation) of OA antibody reactivity to native LL37 or modified LL37 was used as cut-off (dotted line).