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. 2018 Jun 4;165(2):347–360. doi: 10.1093/toxsci/kfy136

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Figure 9. — Dioxin-induced hepatic metabolomic disruption. A, PCA of hepatic metabolomic analysis after 3-day treatment of Tiparp^fl/fl (fl/fl) and Tiparp^fl/flCre^Alb with CO or 10 μg/kg dioxin. B, Venn diagram of the overlapping metabolites that were significantly altered between dioxin treated Tiparp^fl/fl and Tiparp^fl/flCre^Alb. Metabolic pathway enrichment analysis of altered hepatic metabolites (p < .05) in dioxin-treated Tiparp^fl/flCre^Alb (C) and Tiparp^fl/fl mice (D). Hepatic levels of gamma-glutamyl-epsilon lysine (E), N-acetylputrescine (F), putrescine (G), nicotinamde ribonucleoside (H), nicotinamide (I), and NAD⁺ (J). Data represent the mean ± SEM (n = 6–8).