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. 2017 Apr 13;22(4):629. doi: 10.3390/molecules22040629

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cordycepin treatment inhibited tumor growth, prolonged survival time and maintained organ functions. The tumor-bearing mice received PBS, and 25 mg/kg or 50 mg/kg cordycepin five days a week for eight weeks. (a) Cordycepin at 50 mg/kg delayed tumor growth compared with PBS and cordycepin at 25 mg/kg (* p < 0.05); (b) the survival time was prolonged in 50 mg/kg cordycepin group compared with the other two groups (* p < 0.05). The change in weight (c) and laboratory parameters including, white blood cell counts (d) serum alanine aminotransferase (ALT) levels (e), and serum creatinine levels (f) were not significantly different among the three groups of tumor-bearing mice.

Cordycepin treatment inhibited tumor growth, prolonged survival time and maintained organ functions. The tumor-bearing mice received PBS, and 25 mg/kg or 50 mg/kg cordycepin five days a week for eight weeks. (a) Cordycepin at 50 mg/kg delayed tumor growth compared with PBS and cordycepin at 25 mg/kg (* p < 0.05); (b) the survival time was prolonged in 50 mg/kg cordycepin group compared with the other two groups (* p < 0.05). The change in weight (c) and laboratory parameters including, white blood cell counts (d) serum alanine aminotransferase (ALT) levels (e), and serum creatinine levels (f) were not significantly different among the three groups of tumor-bearing mice.