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. 2018 Sep 16;24:6506–6516. doi: 10.12659/MSM.910969

Figure 2.

Figure 2

MicroRNA-7-5p (mir-7-5p) inhibits DNA repair in cisplatin-resistant cells and maintains energy homeostasis. (A, B) The protein level of γH2AX and H2AX in cisplatin-resistant cervical cancer cells or respective control (parental) cells, measured by Western blot. (C, D) The protein level of γH2AX and H2AX in cisplatin-resistant cervical cancer cells were blocked endogenous miR-7-5p with ASO- microRNA-7-5p (mir-7-5p), measured with Western blot following cisplatin treatment. (E) The ratio of ATP/ADP in cisplatin-resistant cervical cancer cells and control (parental) cells with indicated treatments were measured. (F) The ratio of ATP/ADP in cisplatin-resistant cervical cancer cells transfected with ASO-miR-7-5P following cisplatin treatment was measured. * p<0.05, ** p<0.01, ns – no significance.