Figure 4.

Poly (ADP-ribose) polymerase 1 (PARP-1) is the functional target of microRNA-7-5p (mir-7-5p) in cisplatin-resistant cervical cancer cells. (A, B) The protein levels of γH2AX and H2AX in cisplatin-resistant cervical cancer cells with indicated treatment were measured by Western blot. (C) The ratio of ATP/ADP in cisplatin-resistant cervical cancer cells with indicated treatment was measured. (D) Apoptosis of cisplatin-resistant cervical cancer cells with indicated treatment was measured by flow cytometry. * p<0.05, ** p<0.01.