Table 3. Respiratory variables measured using whole body plethysmography during a brief hypoxic respiratory challenge.
Data are provided for both the control (Con) and transplant groups (NPC), and include the inspiratory duration (Ti), expiratory duration (Te), minute ventilation (VE), peak inspiratory airflow (PIF) and peak expiratory airflow (PEF). The tidal volume and breathing frequency data are shown in Figure 4. The results of the two way repeated measures ANOVA are provided including the treatment effect (Con vs. NPC), time effect (4 vs. 8 wks), and the treatment x time interaction.
| Group | Variable | Value | Treat-ment | Time | Treat-ment x | |
|---|---|---|---|---|---|---|
| 4 wk | Con | Ti (sec) | 0.170±0.032 | 0.055 | 0.842 | 0.011 |
| NPC | 0.179±0.029 | |||||
| 8 wk | Con | 0.156±0.023 | ||||
| NPC | **0.189±0.023 | |||||
| 4 wk | Con | Te (sec) | 0.313±0.062 | 0.325 | 0.346 | 0.009 |
| NPC | 0.309±0.059 | |||||
| 8 wk | Con | 0.281±0.068 | ||||
| NPC | *0.348±0.083 | |||||
| 4 wk | Con | VE (ml/min) | 353±88 | 0.503 | 0.203 | 0.119 |
| NPC | 399±61 | |||||
| 8 wk | Con | 416±62 | ||||
| NPC | 386±76 | |||||
| 4 wk | Con | VE (*100g−1) | 137±35 | 0.746 | 0.370 | 0.214 |
| NPC | 148±24 | |||||
| 8 wk | Con | 154±17 | ||||
| NPC | 142±62 | |||||
| 4 wk | Con | PIF (ml/sec) | 24.0±5.8 | 0.607 | 0.087 | 0.182 |
| NPC | 26.2±3.7 | |||||
| 8 wk | Con | 27.5±3.3 | ||||
| NPC | 26.2±3.4 | |||||
| 4 wk | Con | PEF (ml/sec) | 17.0±3.5 | 0.441 | 0.149 | 0.300 |
| NPC | 18.5±3.1 | |||||
| 8 wk | Con | 19.5±2.3 | ||||
| NPC | 18.8±2.3 | |||||
**
indicates p<0.05 vs. CON at 8 wks
*
indicates p<0.05 vs. NPC at 4 wks