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Membrane permeability of 1 determined by Caco-2 assays.
| Molecule | Test Conc. (µM) |
Assay duration (h) |
Mean A → B Papp 10−6 cm/s−1 |
Mean B → A Papp 10−6 cm/s−1 |
Efflux Ratio |
|---|---|---|---|---|---|
| Ranitidine | 10.0 | 2.0 | 0.237 | 1.14 | 5.00 |
| Talinolol | 10.0 | 2.0 | 0.0517 | 3.92 | 76.8 |
| UT-800(1) | 10.0 | 2.0 | 3.39 | 18.3 | 5.44 |
| Warfarin | 10.0 | 2.0 | 35.2 | 28.0 | 0.794 |
