Table 2.

Prognostic value of IER3 protein expression for the overall survival by Cox proportional hazards model

	Univariable			Multivariable
	Hazard Ratio	95% CI	P	Hazard Ratio Ratio	95% CI	p
Gender
Male vs. Female	1.14	0.62–2.10	0.681
Age	1.03	1.00–1.05	0.029	1.04	1.01–1.07	0.012
pT
> =pT3 vs. <=pT2	2.39	1.29–4.42	0.006	1.54	0.71–3.32	0.272
pN
pN(+) vs. pN(−)	3.41	1.95–5.99	< 0.001	2.35	1.26–4.38	0.007
LVI
LVI(+) vs. LVI(−)	2.03	1.22–3.37	0.006	0.99	0.52–1.89	0.987
PNI
PNI(+) vs. PNI(−)	1.03	0.56–1.87	0.935
STSM
STSM(+) vs. STSM(−)	2.62	1.41–4.88	0.002	2.02	0.96–4.27	0.065
Metastasis
Mets(+) vs. Mets(−)	2.35	1.41–3.97	0.001	1.81	0.98–3.33	0.058
IER3 IHC
IER3(high) vs. IER3(low)	2.16	1.29–3.13	0.003	2.21	1.21–4.04	0.010

Bold values indicate that they are less than 0.05