Table 2.

Estimated overall effect size and p values for continuous scores on molecular, histopathological, and clinical variables from fixed effects model

Variable	Continuous score	Effect size	p value
CMS1 subtype	PCSS1	0.82	3E-55
	PCSS2	− 2.55	1E-129
CMS2 subtype	PCSS1	− 2.00	2E-156
	PCSS2	0.76	7E-60
CMS3 subtype	PCSS1	− 0.57	2E-28
	PCSS2	− 0.75	6E-56
CMS4 subtype	PCSS1	1.72	2E-130
	PCSS2	1.75	4E-106
MSI	PCSS1	0.76	1E-31
	PCSS2	− 1.68	5E-71
Right location	PCSS1	0.087	0.09
	PCSS2	− 0.23	1E-04
Late stage	PCSS1	0.16	0.002
	PCSS2	0.24	6E-06
High grade	PCSS1	0.33	3E-05
	PCSS2	− 0.30	7E-05
Disease recurrence or death	PCSS1	0.23	5E-05
	PCSS2	0.19	0.001

The effect size statistic is log hazard ratio for disease recurrence or death and log odds ratio for all other variables. These estimates are not sensitive to fixed vs random effects modeling (Additional file 5: Table S4). Statistics for individual datasets, including I² statistics, are also provided in Additional file 5: Table S4