Table 3.
Univariate and Multivariate Analysis, Cox Model
| Univariate analysis | Hazard ratio | CI | p-Value |
|---|---|---|---|
| Local progression-free survival | |||
| Age | |||
| ≤45 years | 1 | ||
| >45 years | 0.951 | 0.216–4.192 | 0.948 |
| KPS | |||
| ≤80 | 1 | ||
| >80 | 0.383 | 0.088–1.680 | 0.203 |
| CCI score | |||
| <6 | 1 | ||
| ≥6 | 1.271 | 0.489–3.303 | 0.622 |
| T-stage | |||
| No | 1 | ||
| Yes | 0.936 | 0.302–2.901 | 0.908 |
| N-status | |||
| N0 | 1 | ||
| N1 | 1.034 | 0.336–3.185 | 0.954 |
| M-status at RT | |||
| M0 | 1 | ||
| M1 | 0.957 | 0.64–2.517 | 0.929 |
| Gross tumor volume | |||
| Quartile 1–3 | 1 | ||
| Quartile 4 | 1.262 | 0.671–2.371 | 0.470 |
| Pathology | |||
| Low risk | 1 | ||
| High risk | 0.426 | 0.149–1.217 | 0.111 |
| RT after surgery | |||
| ≤3 months | 1 | ||
| >3 months | 1.092 | 0.413–2.888 | 0.860 |
| Concurrent chemo with IMRT | |||
| No | 1 | ||
| Yes | 0.314 | 0.100–0.984 | 0.047 |
| Multivariate analysis | |||
| Pathology | |||
| Low risk | 1 | ||
| High risk | 0.414 | 0.145–1.181 | 0.099 |
| Concurrent chemo with IMRT | |||
| No | 1 | ||
| Yes | 0.306 | 0.097–0.959 | 0.042 |
| Distant metastasis-free survival | |||
| Univariate analysis | |||
| Age | |||
| ≤45 years | 1 | ||
| >45 years | 3.361 | 0.765–14.759 | 0.108 |
| KPS | |||
| ≤80 | 1 | ||
| >80 | 1.792 | 0.514–6.251 | 0.360 |
| CCI score | |||
| <6 | 1 | ||
| ≥6 | 4.137 | 1.144–14.957 | 0.030 |
| T-Stage | |||
| No | 1 | ||
| Yes | 0.672 | 0.217–2.079 | 0.490 |
| N-Status | |||
| N0 | 1 | ||
| N1 | 1.336 | 0.440–4.056 | 0.609 |
| Gross tumor volume | |||
| Quartile 1–3 | 1 | ||
| Quartile 4 | 0.934 | 0.349–2.498 | 0.892 |
| Pathology | |||
| Low risk | 1 | ||
| High risk | 1.698 | 0.697–4.134 | 0.244 |
| RT after surgery | |||
| ≤3 months | 1 | ||
| >3 months | 0.577 | 0.226–1.476 | 0.251 |
| Concurrent chemo with IMRT | |||
| No | 1 | ||
| Yes | 0.761 | 0.313–1.852 | 0.547 |
| Multivariate analysis | |||
| Age | |||
| ≤45 years | 1 | ||
| >45 years | 3.078 | 0.692–13.701 | 0.140 |
| CCI score | |||
| <6 | 1 | ||
| ≥6 | 3.545 | 0.976–12.875 | 0.055 |
| Overall survival | |||
| Univariate analysis | |||
| Age | |||
| ≤45 years | 1 | ||
| >45 years | 4.384 | 0.595–32.318 | 0.147 |
| KPS | |||
| ≤80 | 1 | ||
| >80 | 2.130 | 1.047–4.334 | 0.037 |
| CCI score | |||
| <6 | 1 | ||
| ≥6 | 2.426 | 1.147–5.133 | 0.020 |
| T-Stage | |||
| No | 1 | ||
| Yes | 1.226 | 0.503–2.989 | 0.654 |
| N-Status | |||
| N0 | 1 | ||
| N1 | 1.048 | 0.453–2.427 | 0.913 |
| M-Status at RT | |||
| M0 | 1 | ||
| M1 | 2.568 | 1.236–5.335 | 0.011 |
| Gross tumor volume | |||
| Quartile 1–3 | 1 | ||
| Quartile 4 | 1.484 | 0.628–3.506 | 0.368 |
| Pathology | |||
| Low risk | 1 | ||
| High risk | 0.980 | 0.488–1.969 | 0.955 |
| RT after surgery | |||
| ≤3 months | 1 | ||
| >3 months | 0.951 | 0.471–1.920 | 0.889 |
| Concurrent chemo with IMRT | |||
| No | 1 | ||
| Yes | 0.468 | 0.220–0.994 | 0.048 |
| Multivariate analysis | |||
| Age | |||
| ≤45 years | 1 | ||
| >45 years | 4.220 | 0.538–33.111 | 0.171 |
| KPS | |||
| ≤80 | 1 | ||
| >80 | 1.581 | 0.749–3.339 | 0.230 |
| CCI score | |||
| <6 | 1 | ||
| ≥6 | 0.610 | 0.084–4.415 | 0.625 |
| M-status at RT | |||
| M0 | 1 | ||
| M1 | 2.864 | 0.415–19.754 | 0.286 |
| Concurrent chemo with IMRT | |||
| No | 1 | ||
| Yes | 0.395 | 0.182–0.859 | 0.019 |
CI, 95% confidence interval.