Table 1.
Baseline Characteristics According to Thyroid Functional Status
| Euthyroid (n = 49,791) | Hypothyroid (n = 3065) | p-Value | |
|---|---|---|---|
| TSH, mIU/L | |||
| Median | 1.7 | 6.0 | <0.001 |
| IQR | 1.2–2.4 | 5.1–8.2 | |
| Min–max | 0.3–4.7 | 4.7–204.0 | |
| Age (years), M ± SD | 52 ± 17 | 57 ± 1 | <0.001 |
| Sex, % | |||
| Male | 36 | 34 | <0.001 |
| Female | 64 | 67 | |
| BMI (kg/m2), M ± SD | 26.6 ± 6.0 | 26.8 ± 6.3 | = 0.04 |
| Race, % | |||
| White | 76 | 82 | <0.001 |
| Black | 9 | 5 | |
| Asian | 13 | 12 | |
| Other | 2 | 2 | |
| Ethnicity, % | |||
| Hispanic | 9 | 11 | <0.001 |
| Non-Hispanic | 92 | 89 | |
| Diabetes, % | |||
| Yes | 4 | 6 | <0.001 |
| No | 96 | 94 | |
| Hypertension, % | |||
| Yes | 3 | 3 | = 0.55 |
| No | 98 | 97 | |
| Hyperlipidemia, % | |||
| Yes | 2 | 1 | = 0.20 |
| No | 98 | 99 | |
| CHF, % | |||
| Yes | 0.7 | 0.8 | = 0.37 |
| No | 99.3 | 99.2 | |
| CAD, % | |||
| Yes | 0.6 | 0.7 | = 0.68 |
| No | 99.4 | 99.3 | |
| CVD, % | |||
| Yes | 1.1 | 1.7 | = 0.003 |
| No | 98.9 | 98.3 | |
| AFib, % | |||
| Yes | 1.48 | 2.87 | <0.001 |
| No | 98.52 | 97.73 | |
| Thyroid hormone supplementation use, % | |||
| Yes | 5.5 | 20.4 | <0.001 |
| No | 94.5 | 79.6 | |
| Antithyroid medication use, % | |||
| Yes | 0.1 | 0.4 | = 0.01 |
| No | 99.9 | 99.6 | |
| Prior history of thyroid disease, % | |||
| Yes | 0.83 | 4.21 | <0.001 |
| No | 99.17 | 95.79 | |
| Prior thyroidectomy/RAI ablation, % | |||
| Yes | 0.61 | 1.86 | <0.001 |
| No | 99.39 | 98.14 |
TSH, thyrotropin; IQR, interquartile range; SD, standard deviation; BMI, body mass index; CHF, congestive heart failure; CAD, coronary artery disease; CVD, cerebrovascular disease; AFib, atrial fibrillation; RAI, radioactive iodine.