Table 1.

List of the heparins tested for the anti-hepcidin property in vitro and/or in vivo. These include anti-coagulant and non-anticoagulant heparins as indicated. The main features and the anti-hepcidin potency (*** strong anti-hepcidin activity/** intermediate anti-hepcidin activity/* low anti-hepcidin activity) of the heparins are described. The fractions of fractionated heparins are coded as F plus a number.

	Heparins Tested for Anti-Hepcidin Activity
Compounds	Description	Mw (kD)	Anticoagulant	Potency	Ref.
UFH	Pig Mucosal heparin, commercial (Calciparina)	12.0–15.0	yes	***	[25,27]
PMH	Pig Mucosal heparin (API)	19.9	yes	***	[25,27]
LMWH	Commercial LMWH Enoxaparin (Clexane)	4.5	yes	**	[25,27]
FONDAPARINUX	Commercial pentasaccharide (Arixtra)	1.7	yes	*	[25,27]
RO-82	Glycol-Split,	16.0	no	***	[27,29]
RO-68	Partially 2O-desulfated,Glycol-split	16.4	no	***	[27,29]
NAc-91	N-acetylated	16.0	no	*	[27,29]
NAc-RO-00	N-Acetylated, glycol-split	15.9	no	*	[27,29]
SSLMWH-19	Super-sulfated LMW	8.8	partially	***	[27,29]
PMH-F1	PMH fraction	21.6	yes	***	[29]
PMH-F2	PMH fraction	14.4	yes	***	[29]
PMH-F3	PMH fraction	10.0	yes	***	[29]
RO-82-F1	Glycol-Split, fraction	12.0	no	***	[29]
RO-82-F2	Glycol-Split, fraction	9.2	no	***	[29]
RO-82-F3	Glycol-Split, fraction	7.8	no	**	[29]
RO-82-F4	Glycol-Split, fraction	6.8	no	**	[29]
RO-68-F1	Partially 2O-desulfated Glycol-split	7.8	no	**	[29]
RO-68-F2	Partially 2O-desulfated Glycol-split	6.2	no	**	[29]
RO-68-F3	Partially 2O-desulfated Glycol-split	3.9	no	*	[29]
SSLMWH-19-F1	Super-sulfated LMW fraction	12.9	partially	***	[29]
SSLMWH-19-F2	Super-sulfated LMW fraction	10.3	partially	***	[29]
SSLMWH-19-F3	Super-sulfated LMW fraction	6.9	partially	***	[29]
SSLMWH-19-F4	Super-sulfated LMW fraction	4.0	partially	***	[29]
2-O	PMH 2-O desulfated	-	no	*	[29]
6-O	PMH 6-O desulfated	-	no	*	[29]