. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Transl Res. 2018 Jun 19;198:48–57. doi: 10.1016/j.trsl.2018.05.002

Table I.

IDPs and associated neurodegenerative diseases. Adapted from Uversky⁴⁰.

Protein	Disorder by prediction (%)^a	Function	Disease(s)
Amyloid-β	16.9	Peptidic fragment of APP, which regulates synapse formation, and neuronal plasticity	Alzheimer’s disease Amyloidosis

Tau	77.6	Promote the assembly of and stabilizes neuronal microtubules	Tauopathies Alzheimer’s disease Corticobasal degeneration Pick’s disease Progressive supranuclear palsy

TDP-43	57.3	Transcriptional repression, pre-mRNA splicing, and translational regulation	Amyotrophic lateral sclerosis and frontotemporal lobar degeneration

α-Synuclein	90.7	Regulate synaptic vesicles	Alzheimer’s disease (α) Multiple system atrophy(α) Parkinson’s disease (α, β, γ) Diffuse Lewy body disease (α, β γ)
β-Synuclein	87.3
γ-Synculein	100

FUS	90.7	Transcriptional regulation (initiation & repression), and RNA-binding	Amyotrophic lateral sclerosis

Disorder was predicted by PONDR^® VSL2.