Table 1.

Diagnostic performance (area under the ROC curve + 95% CI) and sensitivity, specificity, positive and negative predictive value (NPV) of the DLS for all cases as well as the validation set separately, and each reader (all data).

	AUC	Sensitivity	Specificity	NPV	PPV
DLS (All)	0.89 (0.83–0.95)	0.78 (.66–.9)	1	1	0.77 (.68–.88)
DLS (Valid.)	0.73 (0.59–0.87)	0.5 (.27–.72)	1	1	0.5 (.41–.65)
Reader 1	0.73 (0.62–0.84)	0.47 (.31–.64)	0.92 (.84–.98)	0.71 (.64–.78)	0.81 (.65–.95)
Reader 2	0.77 (0.68–0.87)	0.78 (.64–.91)	0.66 (.52–.78)	0.8 (.71–.91)	0.62 (.53–.73)
Reader 3	0.73 (0.63–0.83)	0.72 (.58–.86)	0.64 (.52–.76)	0.76 (.67–.86)	0.59 (.50–.70)
Reader 4	0.6 (0.48–0.71)	0.67 (.52–.80)	0.44 (.30–.81)	0.64 (.51–.77)	0.46 (.38–.54)