Table 1.
Properties of MSNs and sequences of short oligonucleotides mentioned in this section.
| MSNs | Nucleic Acids/Fluorophore-Labeled Nucleic Acids | Ref. | ||||
|---|---|---|---|---|---|---|
| MSN Size (nm) | Pore Size (nm) | Surface Coatings | Name | Antisense Strand (5’-3’) | Sense Strand (5’-3’) | |
| ~200 | ~2.71 | Carbosilane dendrons | ssDNACy3 | Cy3-TTATCGCTGATTCAAGACTGA | / | [52] |
| ~180 | / | l-histidine | pDNA-Luciferase | / | / | [53] |
| ~120 | ~2.5 | PEI | pDNA-GFP | / | / | [37] |
| ~70 | ~3.5–5 | Amine with disulfide linker | dsDNA | CTGTGGTTGTGTTTGCACTTT | AGTGCAAACACAACCACAGTT | [54] |
| ~80 | ~2.6 | Poly-arginine | pDNA-mCherry | / | / | [40] |
| ~250 | ~23 | Amine | pDNA-GFP | / | / | [55] |
| ~130 | ~12 | Amine | dsDNA | TCAGAGAGTTAGAGAGTTAGAGAGTCAGAGAGTTAGAGAGTTAGAGAGTCAGAGAGTTAGAGAGTTAGAGAG | CTCTCTAACTCTCTAACTCTCTGACTCTC-TAACTCTCTAACTCTCTGACTCTCTAACTCTCTAACTCTCTGA | [56] |
| ~150 | / | Amine | pDNA-HNF3β | / | / | [46] |
| ~205 | ~2.64 | Amine | pDNA-BMP2 | / | / | [57] |
| ~200 | ~3 | Amine | pDNA-PDGF | / | / | [58] |
| ~74 | / | Poly-amidoamine | miR-34a | UGGCAGUGUCUUAGCUGGUUGU | CAAUCAGCAAGUAUACUGCCCU | [59] |
| ~219.5 | ~18.8 | Bifunctional peptide | miR-29b | GCUGGUUUCAUAUGGUGGUUUAGA | GCUGGUUUCAUAUGGUGGUUUAGA | [60] |
| ~250 | ~3.5 | Calcium | miR-5106 | AGGUCUGUAGCUCAGUUGGCAGA-FAM | UCUGCCAACUGAGCUACAGACCU | [61] |
| ~150 | ~10 | PDMAEMA | siRNA-PLK | UUAAGCAGCUCGUUAAUGGTT-FAM or Cy3 | CCAUUAACGAGCUGCUUAATT | [62] |
| ~130 | ~2.5 | PEI | siRNA-Kras | UUUCCUACUAGGACCAUAGGT | CUAUGGUCCUAGUAGGAAATT | [63] |
| ~100–200 | ~28 | Polylysine | siRNA-MirK | UUCCGGAACAUGAAGUGCCGC | GGCACUUCAUGUUCCGGAAUU | [39] |
| ~100–200 | ~28 | Polylysine | siRNA-S10 | ACGUCGCAGUAACUGUUGCUU | ACGUCGCAGUAACUGUUGCUU | [39] |
| ~100–200 | ~11 | PDMAEA | siRNA-PLK | UUAAGCAGCUCGUUAAUGGTT | CCAUUAACGAGCUGCUUAATT | [64] |
| ~100 | / | PEI | siRNA-HER2 | UUGGGCAUGGACUCAAACGUGUU | CACGUUUGAGUCCAUGCCCAAUU | [65] |
| ~50 | ~3.6 | PEI | siRNA-VEGF | GAUCUCAUCAGGGUACUCCTT | GGAGUACCCUGAUGAGAUCTT | [66,67,68] |
| ~51 | / | PEI | siRNA-Pgp | CGGAAGGCCUAAUGCCGAATT | UUGCGCAUUAGGCCUUCCGTT | [69] |
| ~110 | / | Amine with disulfide linker | PNA-Bcl2 | TCTCCCAGCGTGCGCCAT-Cy5 | / | [70] |
| ~60 | / | Amine | Double-stranded ASOs targeting miR-21 | GTCAACATCAGTCTGATAAGCTATGTCGC-FAM | DABCYL-GCGACATAGCT | [71] |
| ~120 | ~3 | Amine | Antagomir-122 | ACAAACACCATTGTCACACTCCA | / | [72] |
| ~105 | ~3.2 | Amines | Antagomir-21 | UCAACAUCAGUCUGAUAAGCUA | / | [73] |