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. 2017 Mar 23;22(4):514. doi: 10.3390/molecules22040514

Figure 5.

Figure 5

Melanogenesis inhibition on zebrafish embryos treated from 24 hpf to 48 hpf with Morus alba compounds. Bright field images of embryos treated with (A) PTU used as a positive control of melanogenesis inhibition; (B) DMSO used as negative control; (C) 70 μg/mL Morus alba methanol wood extract (MAM); (D) 70 μg/mL CPC F33 fraction that contains the compounds 2,4,3-trihydrodihydrostilbene (7), moracin M (11) and kuwanon G (12); (E) 10 μg/mL CPC F38-42 fraction that contains the compounds oxyresveratrol (1) and trans-dihydromorin (6); (F) 10 μg/mL CPC F43 fraction that contains the compounds oxyresveratrol (1) and dihydrooxyresveratrol (5); (G–L) purified compounds from CPC fractions: (G) 50 μg/mL oxyresveratrol (1); (H) 7 μg/mL kuwanon C (2); (I) 50 μg/mL dihydrooxyresveratrol (5); (J) 50 μg/mL trans-dihydromorin (6); (K) 50 μg/mL 2,4,3′-trihydrodihydrostilbene (7); (L) 10 μg/mL moracin M (11); Scale bar: 100μM.