AD	Alzheimer’s disease
ALS	amyotrophic lateral sclerosis
ATP	adenosine triphosphate
B-Raf	rapidly accelerated fibrosarcoma B
Boc	tert-butyloxycarbonyl
CDI	N,N’-carbonyldiimidazole
CK1	protein kinase CK1, formerly known as casein kinase 1
DCM	dichloromethane
DFG-in/out	sequence motif of aspartic acid (D), phenylalanine (F), and glycine (G) within the activation loop of the kinase domain
DIPEA	N,N-diisopropylethylamine
DMEM	Dulbecco’s modified Eagle’s medium
DMF	N,N-dimethylformamide
DMSO	dimethyl sulfoxide
EDTA	ethylenediaminetetraacetic acid
FASPS	familial advanced sleep phase syndrome
FCS	fetal calf serum
GST	glutathione S-transferase
HPI	hydrophobic pocket I
HRII	hydrophobic region II
JNK	c-Jun N-terminal kinase
LB	lysogeny broth
LCK	lymphocyte-specific protein tyrosine kinase
MAPK	mitogen-activated protein kinase
MTT	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
NaHMDS	sodium bis(trimethylsilyl)amide
NBS	N-bromosuccinimide
NTA	nitrilotriacetic acid
PBS	phosphate-buffered saline
Pd/C	palladium on activated charcoal
pdb	Research Collaboratory for Structural Bioinformatics (RCSB) protein data bank
PEG	polyethylene glycol
PPh3	triphenylphosphine
PyBOP	(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
rt	room temperature
RIPK	receptor-interacting Ser/Thr-protein kinase
RPMI	Roswell Park Memorial Institute medium
SAR	structure-activity relationship
SDS-PAGE	sodium dodecyl sulfate polyacrylamide gel electrophoresis
TBS	Tris-buffered saline
TCEP	tris(2-carboxyethyl)phosphine
THF	tetrahydrofuran
Tris	tris(hydroxymethyl)aminomethane
TTBK	tau tubulin kinase
VRK	vaccinia-related kinase