Table 3.
Effects of COS on the oral bioavailability of caffeic acid derivatives in the FLJ-FF herb couple preparations (Mean ± SD, n = 6).
| Components | Shuang-Huang-Lian Oral Liquid | Yin-Qiao-Jie-Du Oral Liquid | Fufang Qin-Lan Oral Liquid | Qin-Re-Jie-Du Oral Liquid | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caffeic Acid Derivatives | AUC (Control) | AUC (Absorption Enhancer) | Ratio | AUC (Control) | AUC (Absorption Enhancer) | Ratio | AUC (Control) | AUC (Absorption Enhancer) | Ratio | AUC (Control) | AUC (Absorption Enhancer) | Ratio |
| Neochlorogenic acid | 10,646 ± 1009.8 | 81,789 ± 9230.3 ** | 7.6829 | 16,217 ± 2946.9 | 27,324 ± 3763.5 ** | 1.6850 | 7706.5 ± 1066.0 | 28,664 ± 2028.7 ** | 3.7195 | 16,826 ± 4489.8 | 25,208 ± 2157.4 * | 1.4982 |
| Chlorogenic acid | 38,279 ± 5334.8 | 26,428 × 10 ± 40,480 ** | 6.9041 | 43,537 ± 5549.5 | 97,656 ± 16040 ** | 2.2431 | 22,643 ± 4304.1 | 62,547 ± 3675.1 ** | 2.7623 | 44,095 ± 14,327 | 58,100 ± 2892.1 * | 1.3176 |
| Cryptochlorogenic acid | 14,240 ± 1448.9 | 73,548 ± 7090.8 ** | 5.1648 | 17,123 ± 1294.8 | 30,770 ± 6347.8 ** | 1.7970 | 6771.0 ± 1078.0 | 18,832 ± 2037.5 ** | 2.7813 | 23,515 ± 4239.6 | 40,972 ± 754.48 ** | 1.7423 |
| 3,5-dicaffeoylquinic acid | 3460.5 ± 260.90 | 16,812 ± 3170.7 * | 4.8583 | 1730.3 ± 28.868 | 4278.5 ± 686.84 ** | 2.4728 | 1889.6 ± 324.64 | 2911.3 ± 359.13 * | 1.5407 | 2617.8 ± 697.59 | 6460.0 ± 968.28 ** | 2.4678 |
| 3,4-dicaffeoylquinic acid | 814.80 ± 84.113 | 1627.5 ± 9.1924 * | 1.9974 | 1383.0 ± 114.56 | 2769.8 ± 13.435 ** | 2.0027 | 847.53 ± 151.80 | 1955.8 ± 210.57 ** | 2.3077 | 480.73 ± 54.438 | 1313.0 ± 192.84 ** | 2.7313 |
| Isoforsythoside | 2711.0 ± 226.46 | 8080.0 ± 941.16 ** | 2.9805 | 2012.2 ± 65.200 | 4343.3 ± 313.96 * | 2.1585 | 2393.8 ± 129.40 | 2667.0 ± 156.62 | 1.1142 | 5516.7 ± 537.39 | 6750.7 ± 292.74 * | 1.2237 |
| Forsythoside A | 11,776 ± 272.44 | 21,906 ± 369.82 * | 1.8602 | 15,629 ± 2641.4 | 23,727 ± 1224.0 * | 1.5182 | 5581.0 ± 591.26 | 11,555 ± 1131.1 ** | 2.0703 | 10,438 ± 1181.5 | 13,446 ± 354.66 ** | 1.2882 |
| Forsythoside B | 3685.0 ± 328.86 | 14,694 ± 2047.0 ** | 3.9875 | 6678.3 ± 850.79 | 12,440 ± 1564.9 ** | 1.8628 | 1416.5 ± 252.44 | 1868.2 ± 142.50 * | 1.3189 | 1955.0 ± 716.78 | 2532.0 ± 183.95 | 1.2951 |
| Integration | 7294.0 ± 613.83 | 25,748 ± 355.67 ** | 3.5300 | 9139.0 ± 1668.6 | 16,865 ± 1202.1 * | 1.8454 | 5283.0 ± 653.58 | 12,811 ± 2545.9 ** | 2.4249 | 9904.0 ± 886.13 | 14,818 ± 2331.3 * | 1.4962 |
(*) p < 0.05 and (**) p < 0.01, compared with control group.