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Effect of the different conditions for the synthesis of 4a.
| No. | Solvent | Base | Temperature (°C) | Yield (%) a |
|---|---|---|---|---|
| 1 | DMF | Et3N | 25 | 0 |
| 2 | DMF | K2CO3 | 25 | 21 |
| 3 | DMF | K2CO3 | 50 | 38 |
| 4 | acetone | KOH | 25 | 18 |
| 5 | THF | KOH | 25 | 26 |
| 6 | CH3CN | KOH | 25 | 38 |
| 7 | DMF | KOH | 25 | 56 |
| 8 | DMF | KOH | 40 | 87 |
| 9 | DMF | NaOH | 40 | 72 |
a Yields of isolated products.
