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. 2017 Apr 10;22(4):607. doi: 10.3390/molecules22040607

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sequence alignment of DENV serotypes (1–4) with the 4 (I–IV) epitopes for the recognition of antibody 1G5.3. The boxes (colored in green/yellow) highlight the epitopes of each serotype and the critical epitopes responsible for the selectivity of 1G5.3 against the serotypes DENV2/DENV4 are colored in red. The boxes show the five epitopes that are conserved across the DENV1–4 (coloured in yellow), and the also the critical epitope responsible for the selectivity of 1G5.3 against the serotype DENV2 (colored in red). The epitope 24C is highlighted with underline.