Table 2.
Summary of the binder peptides of DENV2 for the antibody 1H7.4 predicted from sequence search only. The peptides which can be considered as potential epitopes are highlighted in bold.
| Peptides | Regions | Sequence | Length (mer) | Secondary Structure | Surface Accessibility | Epitopes |
|---|---|---|---|---|---|---|
| 1H7.4-P1 | 5–13 | vvswknkel | 9 | Turn | Exposed a | |
| 1H7.4-P2 | 27–35 | twteqykfq | 9 | Loop | exposed | 1 |
| 1H7.4-P3 | 65–80 | nlmwkqitpelnhils | 16 | Helix | exposed | |
| 1H7.4-P4 | 97–116 | mqagkrslrpqptelkyswk | 20 | Loop | exposed | 2 |
| 1H7.4-P5 | 125–134 | steshnqtfl | 10 | Loop | exposed | 3 |
| 1H7.4-P6 | 143–151 | cpntnrawn | 9 | Loop | exposed | 4 |
| 1H7.4-P7 | 170–178 | klrekqdvf | 9 | Loop | exposed | 5 |
| 1H7.4-P8 | 187–195 | aikdnravh | 9 | 2β stands | buried | |
| 1H7.4-P9 | 249–264 | gpvsqhnyrpgyytqt | 16 | Loop | dimer interface b | |
| 1H7.4-P10 | 289–297 | edcgnrgps | 9 | Loop | exposed | 6 |
| 1H7.4-P11 | 318–327 | lpplryrged | 10 | β stand | buried |
a peptide is exposed and close to membrane surface (see Figure S1 in Supplementary Materials); b peptide is located on the dimer interface (see Figure S1 in Supplementary Materials).