Table 4.
Summary of the binder peptides of DENV2 for the antibody 1G5.3, predicted from sequence search only. The peptides that can be considered as potential epitopes are highlighted in bold.
| Peptides | Regions | Sequence | Length (mer) | Secondary Structure | Surface Accessibility | Epitopes |
|---|---|---|---|---|---|---|
| 1G5.3-P1 | 3–9 | gcvvswk | 7 | β stand | exposed a | |
| 1G5.3-P2 | 21–29 | itdnvhtwt | 9 | loop | buried | |
| 1G5.3-P3 | 67–82 | mwkqitpelnhilsen | 16 | helix | exposed | |
| 1G5.3-P4 | 111–128 | lkyswktwgkakmlstes | 18 | loop | exposed | I |
| 1G5.3-P5 | 149–159 | awnslevedyg | 11 | β stand | buried | |
| 1G5.3-P6 | 173–181 | ekqdvfcds | 9 | loop | buried b | |
| 1G5.3-P7 | 190–214 | dnravhadmgywiesalndtwkmek | 25 | 2β stands | buried | |
| 1G5.3-P8 | 233–241 | sngvlesem | 9 | loop | exposed | II |
| 1G5.3-P9 | 269–277 | hlgklemdf | 9 | β stand | buried | |
| 1G5.3-P10 | 282–291 | gttvvvtedc | 10 | loop | exposed | III |
| 1G5.3-P11 | 303–312 | asgklitewc | 10 | loop | exposed | IV |
| 1G5.3-P12 | 319–335 | pplryrgedgcwygmei | 17 | 2 β stands | buried |
a peptide is exposed and close to membrane surface (see Figure S2 in Supplementary Materials); b peptide is buried in the dimer form (see Figure S2 in Supplementary Materials).