Table 6.
Summary of the binder peptides of DENV2 for the antibody GUS2, predicted from sequence search only. The peptides that can be considered as potential epitopes are highlighted in bold.
| Peptides | Regions | Sequence | Length (mer) | Secondary Structure | Surface Accessibility | Epitopes |
|---|---|---|---|---|---|---|
| GUS2-P1 | 3–13 | gcvvswknkel | 11 | 2 β stands | exposed a | |
| GUS2-P2 | 27–36 | twteqykfqp | 10 | loop | exposed | A |
| GUS2-P3 | 42–51 | lasaiqkahe | 10 | helix | buried | |
| GUS2-P4 | 63–71 | lenlmwkqi | 9 | helix | exposed | |
| GUS2-P5 | 110–118 | elkyswktw | 9 | loop | exposed | B |
| GUS2-P6 | 124–132 | lsteshnqt | 9 | loop | exposed | C |
| GUS2-P7 | 145–153 | ntnrawnsl | 9 | loop | buried | |
| GUS2-P8 | 196–213 | admgywiesalndtwkme | 18 | 2 β stands | buried b | |
| GUS2-P9 | 249–264 | gpvsqhnyrpgyytqt | 16 | loop | exposed | D |
| GUS2-P10 | 318–327 | lpplryrged | 10 | β stand | buried |
a peptide is exposed and close to membrane surface (see Figure S3 in Supplementary Materials); b peptide is located on the dimer interface (see Figure S3 in Supplementary Materials).