Table 1.

Altered metabolite levels in plasma after oral administration of S1PC to SHRs. ^a

Metabolite b	Control vs. WKY c	S1PC vs. Control c
Betaine	↑↑ d	↓
Tryptophan	↓↓	↑↑
LysoPC(16:0)	↓↓	↑↑
LysoPC(18:3)	↓↓	↑↑
LysoPC(20:4)	↓↓	↑
3-(Acetyloxy)-2-hydroxypropyl icosanoate	↑	↓↓
Caproic acid	↑↑	↓

^a Table was rewritten by referring to a previous study [21]; ^b Blood sample was drawn from the abdominal aorta into vacuum blood collection tubes with EDTA. Samples were analyzed by means of a UltiMate 3000 UHPLC system (Thermo Fisher Scientific, Waltham, MA, USA) coupled with a Q-Exactive quadrupole-Orbitrap mass spectrometer (Thermo Fisher Scientific) [21]; ^c Distilled water was orally administrated to WKY rats and SHRs (Control) once a day for 10 weeks. S1PC (6.5 mg/kg) was orally administrated to SHRs once a day for 10 weeks; ^d ↑: up-regulated (p < 0.05), ↑↑: up-regulated (p < 0.01), ↓: down-regulated (p < 0.05), ↓↓: down-regulated (p < 0.01).