Table 2.

Pharmacokinetic parameters and excretion levels of SMC, SAC, and S1PC in rats and dogs after oral administration. ^a

Animal	Compound	Cmax (mg/L)	T1/2 (h)	AUC (mg·h/L)	BA (%)
Rat	SMC b	1.3 ± 0.33	2.6 ± 0.75	6.0 ± 1.7	95.8
	SAC c	3.9 ± 0.64	1.2 ± 0.19	5.1 ± 0.58	91.9
	S1PC c	4.2 ± 0.92	0.56 ± 0.072	3.2 ± 0.34	88.0
Dog	SMC b	2.6 ± 0.62	8.0 ± 1.1	41 ± 5.3	95.5
	SAC b	2.1 ± 0.14	12 ± 1.2	39 ± 3.5	92.0
	S1PC b	2.0 ± 0.22	5.6 ± 0.58	19 ± 2.4	100

^a Table was rewritten from [28,102]; ^b Oral administration at 2 mg/kg; ^c Oral administration at 5 mg/kg.