Table 6.

Concentration-time profile of GE phenolics following oral dose administration of 250 mg/kg GE with 50 mg/kg ketoconazole in mice.

Time (h)	Concentration (ng/mL)
	6G		8G		10G		6S
	−βgd	+βgd	−βgd	+βgd	−βgd	+βgd	−βgd	+βgd
0	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
0.087	0.31 ± 0.44	1611.34 ± 1136.59	0.48 ± 0.20	31.13 ± 22.39	0.00 ± 0.00	22.80 ± 13.88	0.05 ± 0.07	13.81 ± 15.23
0.167	5.71 ± 4.25	1078.41 ± 788.95	0.63 ± 0.12	25.59 ± 14.92	5.66 ± 5.12	22.03 ± 9.13	0.94 ± 1.33	11.08 ± 8.29
0.25	35.93 ± 44.48	4199.20 ± 5429.93	6.93 ± 9.15	171.88 ± 232.69	20.49 ± 21.65	110.40 ± 138.78	0.00 ± 0.00	22.31 ± 22.45
0.5	37,902.65 ± 53,058.88	35051.01 ± 35340.68	7564.00 ± 10,599.34	5963.41 ± 6931.76	14,015.65 ± 19,653.73	15,312.24 ± 19,191.73	18,637.55 ± 26,338.61	21,051.69 ± 29,448.57
1	103.89 ± 110.27	10,224.71 ± 11,622.13	17.90 ± 19.13	682.37 ± 768.54	54.49 ± 58.26	437.08 ± 369.81	12.46 ± 17.62	170.21 ± 212.35
2	70,928.75 ± 100,284.44	93,896.52 ± 123,421.60	16,340.10 ± 23,104.50	15,805.67 ± 21,666.54	27,873.13 ± 39,392.60	35,370.92 ± 49,184.70	75,903.50 ± 107,343.75	84,223.85 ± 119,013.87
3	65.16 ± 54.26	18,408.37 ± 22,313.19	11.72 ± 7.35	983.51 ± 1199.87	45.84 ± 48.21	603.80 ± 675.86	2.33 ± 3.30	125.05 ± 154.69
4	5.87 ± 1.18	639.17 ± 224.61	2.25 ± 1.56	55.94 ± 15.79	6.52 ± 1.14	142.02 ± 25.61	0.00 ± 0.00	5.17 ± 5.76
6	1.09 ± 0.93	680.17 ± 286.10	3.71 ± 2.18	28.75 ± 14.85	8.07 ± 5.96	62.11 ± 40.75	0.00 ± 0.00	1.20 ± 0.90
8	10.43 ± 11.12	404.60 ± 113.99	1.17 ± 0.11	14.43 ± 2.13	3.71 ± 2.46	25.06 ± 9.52	0.00 ± 0.00	1.19 ± 0.66
12	0.74 ± 1.05	166.32 ± 137.06	0.67 ± 0.17	5.26 ± 5.18	2.61 ± 1.41	9.72 ± 8.83	0.00 ± 0.00	5.27 ± 7.02

−βgd: plasma without β-glucuronidase treatment; +βgd: plasma with β-glucuronidase treatment for 1 h at 37 °C; n = 3 per time point, terminal sampling design, mean ± SD.