Table 2.
Pathological changes in the liver and Ridit analysis.
| Groups | Dosage (mg/kg) | Necrocytosis Grade | Score | Ridit Analysis | |||||
|---|---|---|---|---|---|---|---|---|---|
| n | 0 | 1 | 2 | 3 | 4 | ||||
| Normal | - | 8 | 8 | 0 | 0 | 0 | 0 | 0 | 0.27 |
| APAP | - | 8 | 0 | 2 | 1 | 4 | 1 | 20 | 0.81 ** |
| APAP + BG | 300 | 8 | 5 | 2 | 1 | 0 | 0 | 4 | 0.41 ## |
| APAP + BG | 600 | 8 | 4 | 1 | 2 | 1 | 0 | 8 | 0.51 ## |
Note: The necrocytosis was classed on the basis of the H&E staining of liver sections. The data were analyzed by Ridit analysis. Values represent the mean ± S.D., n = 8. ** p < 0.01 vs. normal group; ## p < 0.01 vs. APAP group. Grading standard: level 0 means have no necrocytosis, normal in the cell of liver; level 1 means liver cells containing necrocytosis of no more than 1/4; level 2 means liver cells containing necrocytosis of no more than 1/2; level 3 means liver cells containing necrocytosis of no more than 3/4; level 4 means liver tissue was almost all of necrocytosis. Level 0 calculated 0 mark; Level I calculated 1 mark; Level II calculated 2 marks; Level III calculated 3 marks; Level IV calculated 4 marks.