Skip to main content
. 2017 Apr 4;22(4):579. doi: 10.3390/molecules22040579

Table 1.

Calculated activity and toxicity in silico profiles for compounds 18 and antiprotozoal choice drugs.

Compound Antiparasitic Effect (Trichomonas vaginalis) LD50 (mg/Kg)
Mouse Rat
Pa Pi ip p.o. ip po
1 0.313 0.023 300 1300 430 1200
2 0.319 0.020 460 1600 330 830
3 0.250 0.065 490 830 530 670
4 0.304 0.027 490 840 460 970
5 0.201 0.122 380 960 800 320
6 0.324 0.018 430 1200 1200 670
7 0.292 0.033 290 920 280 900
8 0.201 0.122 280 1100 440 750
10 0.333 0.015 150 1200 480 620
Bnz 0.705 0.002 1100 280 1300 1100

Pa = Probability of activity Pi = Probability of inactivity ip = Intraperitoneal po = Oral.